Strategic. Personalized. Transformative Care.

Dr. Chris Main is a board-certified orthopedic surgeon with more than 25 years of experience in musculoskeletal care, regenerative medicine, and wellness innovation. He has performed over 30,000 surgical procedures and more than 20,000 precision-guided injections across his career. With deep expertise in Testosterone Optimization, Hormone Replacement Therapy, Medical Weight Loss, Peptide Therapy, and Regenerative Orthopedics, Dr. Main has helped thousands of clients regain strength, vitality, and confidence. His passion for health optimization began in 2012 while evaluating patients for joint replacement surgery. He observed that those with testosterone and vitamin D deficiencies often experienced slower recoveries. That insight sparked a shift in his approach—beyond surgery—toward root-cause wellness solutions that prepare the body for healing and longevity. Today, Dr. Main holds medical licenses in 41 U.S. states, allowing him to extend his evidence-based, client-centered care to individuals across the country. Dr. Main grew up in a tight-knit farming community in rural Missouri, where his parents instilled a strong work ethic and sense of purpose. A standout athlete and nationally ranked pole vaulter and decathlete, he discovered his path to medicine after a serious back injury and extensive rehabilitation. That experience shaped his dedication to helping others recover and perform at their best. He earned his undergraduate degree from Truman State University and completed medical school at the Kirksville College of Osteopathic Medicine, graduating in the top 10% of his class. His residency training was completed at Des Peres Hospital and St. Louis University Hospital. In addition to his role at Ascentis, Dr. Main serves as CEO of several healthcare organizations, including Midwest Orthopedic Surgical Services, The Surgical Care Center, and Evexia Health and Wellness, and as Medical Director for hormone optimization and weight-loss clinics nationwide. He also proudly provides care to military personnel at multiple U.S. Army and Air Force installations. Throughout his career, Dr. Main has published orthopedic and regenerative medicine research, served as a board examiner for the American Osteopathic Academy of Orthopedics, and acted as a team physician for high school and collegiate athletic programs. He takes pride in mentoring the next generation of physicians and continues to support medical students in their clinical training. Outside of medicine, Dr. Main enjoys life with his partner, Alissa, and their blended family. Together, they love cheering on the Mizzou Tigers, Kansas City Chiefs, St. Louis Cardinals, and St. Louis Blues, and can often be found exploring new cities, cooking at home, or discovering unique restaurants. A proud father, bonus dad, and grandfather, Dr. Main centers his life around faith, family, and purpose—values that are reflected in every aspect of his care philosophy.